Myriam Reffay's Group

Laboratoire Matière et Systèmes Complexes - UMR 7057

We are a young and dynamic group based in the Matière et Système Complexes laboratory in the heart of the Paris Rive Gauche district within the Université Paris Cité.

We study the mechanical properties of model tissues in the context of muscle differentiation and tumour progression. Our aim is to determine and understand the organisation and mechanics of these tissues, but also to be able to modify their fate by physical constraints.

RESEARCH INTERESTS

Architecture of model tissues under physical constraints, Mechanobiology of model tissues, Multicellular communication and dynamics, Muscle cell differentiation, Tumoral progression.

TOOLS

Magnetic nanoparticles, multicellular aggregates, manipulation of magnetic aggregates, tissue rheology, tissue microscopy, 2-photons microscopy.

Research Interests

Magnetic multicellular aggregates
Stretching muscle precursor to differentiate them
Macroscopic mechanical properties

Team members

Myriam REFFAY

Associate professor UPC

Contact

Irène NAGLE

PhD Student

Lorijn VAN DER SPEK

PhD Student

Alain RICHERT

Assistant

Latest News

The importance of intermediate filaments in the shape maintenance of myoblast model tissues

Liquid and elastic behaviors of tissues drives their morphology and their response to the environment. They appear as the first insight into tissue mechanics. We explore the role of individual[…]

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Irène Nagle Winner of the L’Oréal Young Talents Prize

Irene was awarded for her work on the mechanical properties of muscle and for highlighting the role of mechanical stress in muscle differentiation by the L’Oréal-Unesco foundation. The announcement of[…]

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