The importance of intermediate filaments in the shape maintenance of myoblast model tissues

Liquid and elastic behaviors of tissues drives their morphology and their response to the environment. They appear as the first insight into tissue mechanics. We explore the role of individual cell properties on spheroids of mouse muscle precursor cells and investigate the role of intermediate filaments on surface tension and Young’s modulus.

Irène Nagle Winner of the L’Oréal Young Talents Prize

Irene was awarded for her work on the mechanical properties of muscle and for highlighting the role of mechanical stress in muscle differentiation by the L’Oréal-Unesco foundation. The announcement of the prize and the presentation of the 35 brilliant laureates can be found at here. Congratulations Irène!!! Bravo Irène !!!

Surface tension accross EMT

Epithelial-mesenchymal transition is not a one-step process but involved various processes. Looking at the action of the metastasis supressor NME1 in model tissues, we highlight an hybrid state of this transition and show that surface tension varies accross EMT as cell-cell adhesion. It can be considered as a marker of both EMT and malignant transformation.